Chemical Profiling of Oxidative Stress Biomarkers and Trace Element Status Associated with Cardiovascular Health among Adults in Mandi District, Himachal Pradesh: A Cross-Sectional Analytical Study

Jul 17

2 min read

Updated: Sep 16

Dr. Amit Thakur, Aadharshila Academy, Jogindernagar, Distt Mandi, Himachal Pradesh 175015
Mrs Sarita Kumari, PGT Chemistry, Govt Sen Sec School, Barot, Distt Mandi Himachal Pradesh 175013
Mr Arvind Thakur, Senior Research Analyst at Abryl Laboratories Dera Bassi
Mrs Seerat Kaur, PGT Chemistry at Sapient Senior Secondary Public School, Pinjore

Corresponding Author:

Dr. Amit Thakur,

Aadharshila Academy,

Jogindernagar, Distt Mandi,

Himachal Pradesh 175015

Abstract

Background: Oxidative stress and disturbances in trace element homeostasis are increasingly recognized as important biochemical factors involved in cardiovascular dysfunction. Alterations in oxidative stress biomarkers and essential trace elements may contribute to endothelial dysfunction, inflammation, lipid peroxidation, and subsequent cardiovascular risk. However, region-specific biochemical data from adult populations in Himachal Pradesh remain limited.

Objective: The present study aimed to evaluate the chemical profile of oxidative stress biomarkers and trace element status and to examine their association with cardiovascular health indicators among adults residing in Mandi District, Himachal Pradesh.

Methods: A cross-sectional analytical study was conducted among adults from Mandi District. Demographic, anthropometric, lifestyle, and cardiovascular parameters, including body mass index, systolic and diastolic blood pressure, were recorded using standardized procedures. Blood samples were analyzed for oxidative stress biomarkers, including malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase, and glutathione-related indices. Serum concentrations of selected trace elements, including zinc, copper, selenium, iron, and magnesium, were determined using appropriate analytical techniques. Lipid profile and other relevant biochemical parameters were also assessed. Correlation and multivariable statistical analyses were performed to determine associations between biochemical markers and cardiovascular risk indicators.

Results: Participants with adverse cardiovascular risk profiles demonstrated comparatively higher oxidative stress, characterized by increased MDA levels and reduced antioxidant defense. Altered concentrations of zinc, copper, selenium, and magnesium were also associated with unfavorable blood pressure and lipid parameters. Increased oxidative stress and trace element imbalance showed significant relationships with selected cardiovascular risk indicators, suggesting an interaction between redox imbalance, micronutrient status, and cardiovascular health.

Conclusion: The findings indicate that oxidative stress and altered trace element homeostasis may be important biochemical correlates of cardiovascular health among adults in Mandi District. Combined assessment of oxidative stress biomarkers and trace elements may provide additional value for identifying individuals with unfavorable cardiovascular risk profiles and may support region-specific preventive strategies.

Keywords: Oxidative stress; Trace elements; Cardiovascular health; Malondialdehyde; Antioxidant status; Zinc; Selenium; Magnesium; Cardiovascular risk; Himachal Pradesh.